Toxicity Profile for Arsine (1993)
Abstract
Arsine was of high acute toxicity when inhaled by laboratory animals and repeated exposures affected the blood, spleen, bone marrow and liver. In humans, arsine inhalation has caused effects on the blood, spleen, nervous system, kidney, liver, heart and lung and, in some cases, may be fatal. In female rats exposed by inhalation after mating fewer pregnancies occurred but no adverse effects on the foetus were detected when pregnant rodents inhaled concentrations that were maternally toxic. No data on the carcinogenic risk to humans from arsine were found, however, inorganic arsenic compounds have been associated with an increased risk of lung cancer. Arsine may irritate the mucous membranes.
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