Toxicity Profile for alpha-Terpineol (2001)
Abstract
In rabbits neat alpha-terpineol was a moderate skin irritant. Two dermatitis patients were reported to be sensitized to alpha-terpineol, although attempts to induce skin sensitization in volunteers and guinea pigs using a dilute solution were unsuccessful. Following acute oral exposure, a low toxicity was generally reported in rodents. Indirect evidence of liver effects was seen in rats given repeated oral doses. No indication of lung carcinogenicity was seen in a limited study in mice (treated by injection). A mutagenic effect was seen in sensitive strains in an Ames bacterial test.
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