Toxicity Profile for Lemon oil (1998)
Abstract
Lemon oil caused irritation and was phototoxic to the skin of laboratory animals. Skin irritancy has also been demonstrated in humans. Attempts to induce skin sensitization in volunteers and guinea pigs were unsuccessful, although a few cases of skin sensitization to lemon oil have been reported in man. A low acute oral and dermal toxicity was indicated in laboratory animals. In mice, lemon oil given orally reduced the carcinogenic action of an established lung and forestomach carcinogen, but its application to the skin increased the activity of a skin carcinogen. Limited studies in bacteria and mammalian cells in culture did not identify any genotoxic potential.
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