Toxicity Profile for Oleylamine (2000)

Abstract

Neat oleylamine was corrosive to rabbit skin. Repeated applications of a dilute solution of (a commercial sample of) oleylamine produced skin irritation in rats. Oleylamine had a moderate to low acute oral toxicity in rodents. Repeated oral administration to rats and rabbits identified no specific target sites for toxicity. Studies in rats, rabbits and mice treated orally during pregnancy have generally produced reassuring results, although foetal toxicity was reported in mice at a dose that was not obviously maternally toxic. Intraperitoneal administration of oleylamine to pregnant mice caused foetal toxicity and malformations. There was no evidence of carcinogenic potential in a limited study where a mixture of oleylamine hydrofluoride and cetylamine hydrofluoride was given in the diet of rats. A single oral administration to mice did not damage the bone marrow chromosomes. Oleylamine did not induce chromosome damage or mutations in mammalian cells in culture, and was not mutagenic in an Ames bacterial assay, although the concentrations that could be tested were limited due to the amine's toxicity.