Quinoline Yellow (1990)
Abstract
In man, Quinoline Yellow induced skin sensitization reactions but, in general, these have been attributed to an impurity. Oral administration has exacerbated pre-existing dermatitis in certain individuals. It was of low acute oral toxicity in rats and no obvious target sites were identified in rats, mice and dogs given repeated oral doses. Quinoline Yellow demonstrated no convincing evidence of carcinogenicity when fed to rodents over long periods. It was inactive in bacterial mutagenicity (Ames) assays. In rats given repeated oral doses, before mating and throughout pregnancy, pup survival was slightly reduced.
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