A recent AFSSA report, which provides an overview of the toxicity (and relevant mechanistic data) of polychlorinated biphenyls, concludes that “the effects of PCBs on the mental and motor development of the child exposed in utero represent the best documented critical effect for establishing a critical [PCB] concentration level in humans”. The Agency proposed a value of 700 ng total PCB/g of plasma lipids as the critical concentration threshold for pregnant women, women of childbearing age, lactating women, and children under three years of age, while for the rest of the population, a critical concentration of 1800 ng PCB/g plasma lipids was suggested. Although the available data evidently indicated that around 90% of French women under 45 have levels below the 700-ng threshold, it was recommended that special attention should be given to monitoring the PCB exposure of women who are (or likely to become) pregnant.

[AFSSA – Request No. 2008-SA-0053. Document dated 5 March 2010. Opinion of the French Food Safety Agency on interpreting the health impact of PCB concentration levels in the French population. Available via http://www.afssa.fr/Documents/RCCP2008sa0053EN.pdf on the AFSSA website.] {185297}

The above item was taken from the July 2010 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).

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