On the basis of rodent toxicity studies, ANSES calculated the following 8-hour OELs, whilst recommending that the concentration corresponding to five times the OEL should not be exceeded over a 15-minute period:

  • Benzylbutyl phthalate (BBzP): 13 mg/m3 based on reproductive toxicity
  • Di-n-butyl phthalate (DnBP): 2 mg/m3 based on reproductive toxicity
  • 2-Ethoxyethanol and 2-ethoxyethyl acetate (EGEE and EGEEA): 1 ppm (3.75 mg/m3 for EGEE and 5.49 mg/ for EGEEA) based on damage to red blood cells
  • Trichloroethylene (TCE): 40 mg/m3, a pragmatic limit to protect against kidney toxicity. This limit would not protect against cancer, which is described as a non-threshold effect.

In its consideration of n-butanol, ANSES had no recommendation for an 8-hour OEL due to the lack of systemic toxicity reported in medium- or long-term studies; the Agency did, however, set a short-term exposure limit (STEL) of 100 mg/m3, to protect against eye irritation.

French Agency for Food, Environmental and Occupational Health & Safety (2017). Occupational exposure limit values. Reports (in French) dated May 2017:

n-Butanol. https://www.anses.fr/en/system/files/VLEP2012SA0083Ra.pdf

Butylbenzyl-phthalate. https://www.anses.fr/en/system/files/VLEP2012SA0224Ra.pdf

2-Ethoxyethanol and 2-ethoxyethyl acetate. https://www.anses.fr/en/system/files/VLEP2010SA0316Ra.pdf

Di-n-butylphthalate. https://www.anses.fr/en/system/files/VLEP2012SA0223Ra.pdf

Trichloroethylene. https://www.anses.fr/en/system/files/VLEP2007SA0432Ra.pdf

 

The above items were taken from the October 2017 issue of Toxicology and Regulatory News which is sent automatically to members of bibra.

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