ANSES has recently issued its assessment of the human health effects of D4 in the workplace. Reproductive toxicity (specifically reduced implantation sites in rats exposed by inhalation) was selected as the critical health effect. An 8‑hour occupational exposure limit (OEL) of 130 mg/m3 and 15-minute short term exposure limit (STEL) of 650 mg/m3 (i.e. five-fold the value of the OEL) were derived.

ANSES has also released a review and assessment of the health risks posed to workers and the general public by crystalline silica.

French Agency for Food, Environmental and Occupational Health & Safety (ANSES) (2018-2019). Opinion on “Updating knowledge on the hazards, exposures and risks associated with crystalline silica”. ANSES Opinion Request No 2015-SA-0236 – Crystalline silica. April 2019. Collective expert appraisal: summary and conclusions. Regarding the “expert appraisal for setting occupational exposure limits for chemical agents” Assessment of the health effects and methods for the measurement of exposure levels in workplace atmospheres for octamethylcyclotetrasiloxane, CAS No. 556-67-2. Request n° 2012-SA-0076 – OEL permanent mission. June 2018.


The above items were taken from the November 2019 issue of Toxicology and Regulatory News which is sent automatically to members of bibra.

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