…Proposals for harmonised classification and labelling

Under EC Regulation No. 1272/2008 on Classification, Labelling and Packaging, there is a legal obligation for suppliers to evaluate the hazards of chemicals (substances and mixtures) to be placed on the market, and to classify and label them appropriately. An option also exists for Member State competent authorities or industry to ask for the classification and labelling of a substance to be harmonised across Europe, whereupon the European Chemicals Agency organises a public consultation period of 45 days. Under this scheme, proposals have been recently submitted by the German and UK/Dutch authorities to standardise the classification of indoxacarb, 2-ethoxyethanol, vinyl acetate and a mixture of two isomers of 2,4,4‑trimethylpentene. To view the relevant background scientific reports, obtain further information, or comment on these proposals (by 4 or 11 October 2010), is the place to visit. {186073-5; 186125}

…Tris[2-chloro-1-(chloromethyl)ethyl] phosphate – harmonised classification proposal

ECHA’s Committee for Risk Assessment (RAC) has agreed with the proposal from Ireland to classify this flame retardant as a carcinogen throughout the EU. No harmonised classification currently exists for this substance at EU level. The Committee’s opinion is available (via http://echa.europa.eu/about/organisation/committees/rac/committee_opinions_en.asp) on the website of the European Chemicals Agency. {186235}

…ECHA consults on substances of very high concern

Member State competent authorities and the European Chemicals Agency may prepare Annex XV dossiers for substances of very high concern as defined in Article 57 of the REACH regulation. These include substances that are carcinogenic, mutagenic or toxic to reproduction (CMR), persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB). The latest batch of dossiers of toxicological interest to be issued cover cobalt(II) sulphate, dinitrate, carbonate and diacetate, chromium trioxide and acids generated from the trioxide and their oligomers, 2‑methoxyethanol and 2-ethoxyethanol. These documents are all dated 30 August 2010, and can be obtained (with ‘commenting forms’ for submission by 14 October 2010) from ECHA (by visiting . {186129-36}

…IUCLID 5.2.2 is available to download

For those who may have missed our ‘hot off the press’ announcement accompanying the last issue (number 9) of Toxicology and Regulatory News, IUCLID 5.2.2 has replaced the previous version 5.2.1 and resolves compatibility issues introduced in that version. The new software is available via http://iuclid.eu/index.php?fuseaction=home.iuclidHome from the IUCLID 5 website.

…Other REACH documents of interest

Calls for information to avoid unnecessary animal testing:

1,6-bis((dibenzylthiocarbamoyl)disulfanyl)hexane – reproductive/developmental toxicity;
(1‑methylethylidene)di-4,1-phenylenetetraphenyl diphosphate – sub-chronic (90-day) oral toxicity;
1,5-bis[1,2-bis(ethoxycarbonyl)ethylamino]-2-methylpentane – sub-chronic (90-day) oral toxicity and reproductive/developmental toxicity (http://echa.europa.eu/consultations/test_proposals/test_prop_cons_en.asp).

Practical examples of exposure scenarios for the semiconductor industry (http://echa.europa.eu/doc/press/na_10_48_exposure_scenarious_semiconductor_industry_20100906.pdf).

The above items were taken from the October 2010 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).

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