Not many chemicals hit the headlines, but BPA has had this dubious honour following the recent publication of a study that is bound to give the expert groups yet more food for thought (as if they didn’t already have enough to get their collective teeth into). The study, which involved nearly 1500 US adults, reported an association between high urinary BPA concentrations and an increased risk of cardiovascular disease and diabetes (odds ratios for individuals in the highest BPA concentration quartile compared with those in the lowest: 2.89, 95% CI 1.07-7.78 and 2.43, 95% CI 1.35-4.38, respectively). In addition, higher BPA levels in the urine were linked with increased concentrations of various liver enzymes in the blood (Lang I.A. et al., Journal of the American Medical Association 2008, 300, 1303). In view of BPA’s toxicological profile and extensive use, an accompanying editorial suggests that “even while awaiting confirmation of the findings of Lang et al., decreasing exposure to BPA and developing alternatives to its use are the logical next steps to minimize risk to public health” (vom Saal F.S. and Myers J.P., ibid. 2008, 300, 1353). {178865-6}

The above item was taken from the October 2008 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).

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