The Committee on Mutagenicity (COM) has published its conclusions on Cell Transformation Assays (CTAs). Briefly, these are:

  • Syrian hamster embryo (SHE) CTAs are widely used but do not discriminate between genotoxic and non-genotoxic carcinogens
  • the available evidence is not sufficient to recommend routine regulatory use of the SHE (pH 6.7 or pH 7.0), BALB/c 3T3 or Bhas42 CTAs
  • future validation of these assays will require the use of a wide range of carcinogens and non-carcinogens, the development of objective biological markers of cell transformation, quality control procedures for assessment of subjective morphology assessments of transformed colonies or foci and a greater understanding of the molecular mechanism(s) involved in cell transformation

UK Committee on Mutagenicity of Chemicals in Food, Consumer Products and the Environment.

Statement on Cell Transformation Assays. Referral, COM/12/S4, October 2012.


The above item was taken from the December 2012 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).

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