The Committee on Mutagenicity has published A Strategy for Testing of Chemicals for Genotoxicity. The 2011 Guidance document recommends a staged approach to testing chemicals with no existing genotoxicity data. Stage 0 consists of preliminary considerations which include physico-chemical properties, toxicological properties, structure-activity relationships and information from screening tests. A “core-test battery” consisting of the Ames test combined with the in vitro micronucleus test is recommended for Stage 1 in vitro testing. For Stage 2 in vivo genotoxicity testing, the COM recommends the core tests of rodent micronucleus/chromosome aberrations assays for aneuploidy and clastogenicity, transgenic rodent gene mutation assay and the rodent Comet assay for DNA damage, but advises that the strategy be developed on a case-by-case basis in response to observations made at the earlier stages.

UK Committee on Mutagenicity of Chemicals in Food, Consumer Products and the Environment. Guidance Statements: A Strategy for Testing of Chemicals for Genotoxicity. 2011.

http://www.iacom.org.uk/guidstate/documents/COMGuidanceFINAL2.pdf

The above item was taken from the January/February 2012 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).

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