DECOS has drafted an evaluation of the carcinogenic potential of 1,2-dibromoethane, classified in the European Union as “presumed to have carcinogenic potential for humans” (category 1B), and believed to interact directly with DNA. The Committee established “health-based calculated occupational cancer risk values” (HBC-OCRVs), which associate occupational (40-year) exposures at 0.5 or 0.05 μg/m3 with additional lifetime cancer risks of 1 in 100,000 or 1 in a million, respectively.

In its finalised evaluation of the carcinogenic potential of vinyl chloride, DECOS maintained its opinion that this substance is “known to have carcinogenic potential for humans” (category 1A) and acts via a stochastic (i.e. non-threshold) genotoxic mechanism. The calculated HBC-OCRVs imply additional lifetime cancer risks of 1 in 100,000 and 1 in a million at occupational exposures of 164 and 16 μg/m3, respectively.

Dutch Expert Committee on Occupational Safety, a Committee of the Health Council of the Netherlands (2017). 1,2‑Dibromoethane. Health‑based recommendation on occupational exposure limits. Draft, 2 February 2017.

https://www.gezondheidsraad.nl/sites/default/files/2017_ocr_12-dibroomethaan.pdf

Vinyl chloride monomer. Health-based calculated occupational cancer risk values. 22 February 2017. https://www.gezondheidsraad.nl/sites/default/files/201701vinyl_chloride_monomer.pdf

 

The above items were taken from the April 2017 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here)

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