DECOS has drafted an evaluation of the carcinogenic potential of 1,2-dibromoethane, classified in the European Union as “presumed to have carcinogenic potential for humans” (category 1B), and believed to interact directly with DNA. The Committee established “health-based calculated occupational cancer risk values” (HBC-OCRVs), which associate occupational (40-year) exposures at 0.5 or 0.05 μg/m3 with additional lifetime cancer risks of 1 in 100,000 or 1 in a million, respectively.
In its finalised evaluation of the carcinogenic potential of vinyl chloride, DECOS maintained its opinion that this substance is “known to have carcinogenic potential for humans” (category 1A) and acts via a stochastic (i.e. non-threshold) genotoxic mechanism. The calculated HBC-OCRVs imply additional lifetime cancer risks of 1 in 100,000 and 1 in a million at occupational exposures of 164 and 16 μg/m3, respectively.
Dutch Expert Committee on Occupational Safety, a Committee of the Health Council of the Netherlands (2017). 1,2‑Dibromoethane. Health‑based recommendation on occupational exposure limits. Draft, 2 February 2017.
Vinyl chloride monomer. Health-based calculated occupational cancer risk values. 22 February 2017. https://www.gezondheidsraad.nl/sites/default/files/201701vinyl_chloride_monomer.pdf
The above items were taken from the April 2017 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here)News Home Guest Write For Us? Contact Us