The Dutch Expert Committee on Occupational Safety has released its draft recommendations on occupational exposure limits for bisphenol A and for cadmium and its inorganic compounds. Regarding bisphenol A, DECOS considered there to be very limited evidence to support a non-monotonic dose-response relationship and therefore recommended a health‑based recommended occupational exposure limit (HBROEL) of 3.3 mg/m3 (inhalable fraction), based on a 13‑week inhalation study in rats, the critical effect being local toxicity in the nasal cavity. For cadmium and its inorganic compounds, DECOS reviewed the 2017 recommendation of the Scientific Committee for Occupational Exposure Limits (SCOEL), and considered the scientific basis of its OEL (of 1 µg/m3, inhalable fraction) to be insufficient. DECOS instead supported a previously‑defined biological limit value in the urine of 2 µg cadmium/g creatinine for the protection against kidney effects, and an OEL of 4 µg/m3 to prevent adverse effects on the lungs.

Health Council of the Netherlands (2018). Dutch Expert Committee on Occupational Safety. Drafts public review. Health-based recommendation on occupational exposure limits. Cadmium and inorganic cadmium compounds. https://www.healthcouncil.nl/documents/advisory-reports/draft-reports/draft-reports/01/cadmium-and-inorganic-cadmium-compounds

Bisphenol A. https://www.healthcouncil.nl/documents/advisory-reports/draft-reports/draft-reports/01/bisphenol-a

 

The above items were taken from the November 2018 issue of Toxicology and Regulatory News which is sent automatically to members of bibra.

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