When inhaled, diisocyanate and triisocyanate compounds are respiratory sensitisers capable of causing allergic reactions in the airways. For inhaled allergens, it is generally not possible to derive a concentration below which there is no risk of sensitisation. DECOS (a committee of the Health Council of the Netherlands) therefore considered a “1% extra risk of sensitisation” resulting from occupational exposure (i.e. one additional case in every 100 people) to be tolerable in deriving its health-based advisory concentration of 0.1 µg isocyanate (NCO group)/m3 for an 8-hour working day.

Dutch Expert Committee on Occupational Safety (2018). Di- and triisocyanates. Health-based recommendation on occupational exposure limits. No. 2018/20. The Hague, November 28, 2018.


The above items were taken from the January/February 2019 issue of Toxicology and Regulatory News which is sent automatically to members of bibra.

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