A report from the Danish EPA compares the endocrine disrupting effects of five pesticides …

  • epoxiconazole
  • mancozeb
  • prochloraz
  • tebuconazole
  • procymidone

… when tested alone or as a mixture, in developmental toxicity studies in rats. The mixture, which contained the pesticides at levels below their respective no-observed-adverse-effect levels (NOAELs), produced developmental effects that were not seen with the individual pesticides. Duration of pregnancy and ability to give birth were adversely affected in the dams, while the male offspring showed increased nipple retention and frequency of genital malformations, and decreased reproductive organ weight and sperm count. Blood levels of the pesticides in the offspring were higher from the mixed exposure than from the single pesticides alone. Comparison of the mixture derived-no-effect level (DNEL) with the acceptable daily intakes (ADIs) for the five pesticides indicated that the ADIs may not be sufficiently protective against mixture effects, and that risk assessment procedures for single chemicals may not be conservative enough. The report concludes that risk assessment procedures for pesticides need to be modified “to take account of mixture effects and the potentially serious impact of mixed exposure on development and reproduction in humans”.

Hass U et al. (2012). Developmental toxicity effects in experimental animals after mixed exposure to endocrine disrupting pesticides. Pesticides Research No. 141 2012.


The same study is described in two papers in the peer-reviewed literature.
Hass U et al. Reproductive Toxicology 2012, 34, 261; Jacobsen PR et al. Ibid. 2012, 34, 237.

http://dx.doi.org/10.1016/j.reprotox.2012.05.090; http://dx.doi.org/10.1016/j.reprotox.2012.05.099


The above item was taken from the August 2012 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).

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