NICNAS has finalised its assessment report on DBP, a ubiquitous plasticiser found in many consumer products including cosmetics and children’s toys. A full review of its mammalian toxicology identifies the critical effect for human health as reproductive and developmental toxicity, with the lowest no-observed-adverse-effect level (NOAEL) being 10 mg/kg bw/day (in male offspring of female rats exposed during pregnancy). The margin of exposure (MoE) between the worst-case exposure from toys and the NOAEL for reproductive and developmental effects was around 5000, which was judged sufficiently protective of human health. However, a reasonable worst-case exposure scenario through the use of cosmetics led to an MoE of less than 100, indicating a risk of reproductive toxicity for the general population from the simultaneous use of multiple cosmetic products containing DBP.

Australian National Industrial Chemicals Notification and Assessment Scheme (2013). Priority Existing Chemical Assessment Report No. 36. Dibutyl phthalate. November 2013.


The above items were taken from the December 2013 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here

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