Acrylamide is a known genotoxin, carcinogen and reproductive toxin. Australian investigators now claim to have demonstrated for the first time that chronic exposure of male mice to acrylamide in the drinking water, at a range of doses said to encompass human dietary estimates (0.0001-2.0 mg/kg bw/day), produces DNA damage in their germ cells. This occurred in the absence of overt signs of toxicity or defects in spermatogenesis. The investigators noted that genetic damage in the male germ line may be transmitted to future offspring, and suggested that this could be of relevance to male reproductive health in humans.

Nixon BJ et al. Toxicological Sciences 2012, 129, 135.

http://dx.doi.org/10.1093/toxsci/kfs178

 

The above item was taken from the October 2012 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).

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