2-Ethyl-1-hexanol was a moderate skin, eye and mucous membrane irritant in laboratory animals. Dilute solutions gave no evidence of sensitizing potential in man. Low acute oral and dermal toxicities were indicated in laboratory animals with the principal target in acute oral and inhalation studies being the central nervous system. Repeated oral administration produced effects on the liver of rats and mice including proliferation of peroxisomes (cellular substructures) and kidney degeneration. Oral administration to pregnant rats resulted in foetal malformations whereas foetotoxicity was induced when pregnant mice were treated. A range of genotoxicity screening studies in mice and rats and in mammalian cells in culture failed to generate any convincing evidence of activity. In general, genotoxic activity was not seen in bacterial assays, including Ames mutagenicity tests. 2-Ethyl-1-hexanol has not been tested for carcinogenicity.

Date of Publication: 1990

Number of Pages: 6

CAS Number*: 104-76-7

Format: PDF available for immediate download

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