Occupational exposure to adipic acid may have caused asthma. In laboratory animals, eye and gastro-intestinal irritation have been recorded. It was of moderate to low acute oral toxicity in rodents. Repeated oral administration caused central nervous system effects in rats. No evidence of reproductive effects occurred when laboratory animals were fed adipic acid during pregnancy. A limited carcinogenicity study in rats treated orally found no evidence of activity. Workers exposed to a number of chemicals, including adipic acid, displayed DNA damage in the white blood cells and their urine showed mutagenicity towards bacteria. A range of genotoxicity screening assays (both in vivo and in vitro), including Ames bacterial tests, were essentially negative.

Date of Publication: 1991

Number of Pages: 6

CAS Number*: 124-04-9

7486-38-6

23311-84-4

Format: PDF available for immediate download

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