No toxic effects were seen when rats, mice, hamsters and dogs were fed repeated high doses of beta-carotene. Two multi-generation feeding studies in rats revealed no adverse effects, but mild depression of pup growth and delayed bone development was reported in rat studies in which beta-carotene was fed to females during pregnancy. No reproductive effects were seen when pregnant rabbits were given oral doses. Lifetime feeding studies gave no evidence of carcinogenicity in rats and mice. beta-Carotene was not mutagenic in the Ames bacterial test and did not induce chromosomal damage when fed to mice. Equivocal results have been reported in tests for DNA damage in bacteria. beta-Carotene produced transient irritation in the eye of rabbits.
Date of Publication: 1991
Number of Pages: 11
CAS Number*: 7235-40-7
Format: PDF available for immediate download
Toxicity Profiles A-Z
1-8 A B C D E F G H I K L M N O P Q R S T U V X Z
* CAS Registry Number is a Registered Trademark of the American Chemical Society
Toxicity Profiles Home Become a Member (50% Off Profiles) Contact Us