In man, cyclohexylamine was severely irritating to the skin and may have induced skin sensitization reactions. Oral administration increased blood pressure.

In laboratory animals, cyclohexylamine caused eye damage and irritated the respiratory tract. A moderate to high acute toxicity by the oral, dermal and inhalation routes was recorded in rodents and rabbits. Repeated oral exposure of the hydrochloride caused testicular damage in rats, and had some liver effects in mice, whereas sperm production was disrupted by cyclohexylamine in dogs. Rats exposed repeatedly to cyclohexylamine in the atmosphere exhibited abnormalities at various sites including the thyroid, heart and lungs. Cyclohexylamine and its salts were foetotoxic when administered orally to mice and rats (generally at doses associated with decreased maternal weight gain) and there was some indication of effects on male fertility in rats. No convincing evidence of carcinogenicity was seen in rats or mice treated orally with cyclohexylamine or its salts.

The data from genotoxicity screening assays are contradictory. The positive results reported in a number of systems, both in rodents (treated orally and by injection) and in cells in culture, are matched by a greater weight of negative findings from experiments involving similar or higher exposures. Cyclohexylamine gave essentially negative results in bacterial assays including the Ames test.

Date of Publication: 1991

Number of Pages: 9

CAS Number*: 108-91-8

4998-76-9

19834-02-7

Format: PDF available for immediate download

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