Ethyl methylphenylglycidate (EMPG) irritated the skin of some individuals. Skin sensitization was not induced in volunteers given repeated applications of a dilute solution. EMPG was of low acute oral toxicity in rodents. Long-term feeding studies generated no clear evidence of carcinogenicity, although treated male rats had increased incidences of cellular changes in the liver, pancreas, adrenal glands and lymph nodes. In shorter feeding studies in rats, various organ weight changes, slight paralysis of the hind limbs, together with associate nerve degeneration, and marked wasting of the testes were seen. Chromosome damage occurred in mammalian cells in culture but not in the bone marrow cells of mice given a single intraperitoneal injection. There was no evidence of mutagenicity in bacterial assays (including Ames tests) although a weak mutagenic effect was seen in the fruit fly.

Date of Publication: 2001

Number of Pages: 6

CAS Number*: 77-83-8

Format: PDF available for immediate download

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