In a volunteer study, ethyl vanillin (EV) demonstrated no sensitizing potential but was a skin irritant. Acute oral toxicity was low by the oral route in rats and rabbits although a high oral dose caused central nervous system effects and coma in rats and rabbits. In rats and rabbits treated by multiple oral dosing, cellular changes were seen in the heart, lungs, liver and kidneys. A limited long-term feeding study generated no evidence of carcinogenicity. EV did not cause structural damage to mammalian chromosomes in vivo or in vitro. It was non-mutagenic in the bacterial Ames test and did not induce heritable mutations in fruit flies.

Date of Publication: 1988

Number of Pages: 4

CAS Number*: 121-32-4

Format: PDF available for immediate download

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