Fumaric acid is a normal body metabolite in man. The acid and its common salts were of low acute oral and dermal toxicity in rats and rabbits. Testes degeneration was evidently induced in rats given repeated oral doses of the acid. Intraperitoneal injection produced liver damage in rats treated with fumaric acid, and thyroid and pituitary effects, testes damage and hormonal changes in rabbits treated with sodium fumarate. In limited feeding studies, the acid had no reproductive effects in the guinea-pig and gave no evidence of carcinogenicity in rats. Fumaric acid was not mutagenic in Ames bacterial tests, and did not induce chromosomal damage in mammalian cells in culture. The acid severely irritated the eyes of rabbits and has been described as mildly irritant to human skin.

Date of Publication: 1991

Number of Pages: 5

CAS Number*: 110-17-8




Format: PDF available for immediate download

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