Peppermint oil was of low acute oral toxicity to rats and mice, although high doses caused gastro-intestinal, liver and central nervous system effects. Brain lesions and kidney injury have been reported in rats given repeated oral doses. Oral studies in mice and dogs failed to reveal similar effects. There were suggestions of immunosuppression in mice treated orally. Peppermint oil was not mutagenic in a limited Ames bacterial test but there was indirect evidence of DNA damage in other bacteria. Equivocal results have been reported in assays for chromosomal damage in mammalian cells in culture.
Date of Publication: 1999
Number of Pages: 10
CAS Number*: 8006-90-4
Format: PDF available for immediate download
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