Polyethylene glycol 400 (PEG 400) has caused skin irritation in a few individuals and slight eye effects. Some irritation has resulted in experimental animals from its application to the skin and eyes. Sensitization and intolerance reactions have occasionally been reported in humans exposed to PEG 400 in topical medicaments. It was of very low acute oral toxicity in a range of animal species, causing damage to the digestive tract and diarrhoea at high dose levels. Repeated feeding produced changes in liver and kidney weights in rats.

Date of Publication: 1990

Number of Pages: 7

CAS Number*: 25322-68-3

Format: PDF available for immediate download

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