Tri-n-butyl phosphate was a severe irritant to the skin, eyes and respiratory tract of humans and laboratory animals but did not induce sensitization. It caused nausea and headaches in workers exposed to the vapours. In laboratory animals, it was of low to moderate acute toxicity by the oral, inhalation and dermal routes. The nervous system, liver, kidneys, bladder and testes were identified as the principal target sites. No chromosomal damage was induced in mammalian cells in culture. Mutagenicity tests in Ames bacterial assays gave inconsistent results.

Date of Publication: 1991

Number of Pages: 7

CAS Number*: 126-73-8

Format: PDF available for immediate download

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