A range of toxic effects have developed in vinyl chloride-exposed workforces, with the bones, blood, liver and spleen being the principal sites of attack. In repeated oral and inhalation studies in laboratory animals, the most common target of vinyl chloride’s toxic action was the liver. Acute exposure to high concentrations did not cause any immediate overt effects.
An increased miscarriage rate has been reported among the wives of men occupationally exposed to vinyl chloride. Reproductive inhalation studies in several species of laboratory animals indicated a reduced fertility in rats and a weak foetotoxic action in mice, but provided little evidence of any ability to induce malformations.
Date of Publication: 1991
Number of Pages: 8
CAS Number*: 75-01-4
Format: PDF available for immediate download
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