Ahead of a peer-review meeting later in the year, the US EPA has released draft documents summarising the human health effects of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS). The Agency has proposed oral reference doses (RfDs) of 20 and 30 ng/kg bw/day for PFOA and PFOS, respectively, based on liver effects (for both compounds) and developmental toxicity (for PFOS). In each case, evidence for carcinogenicity was “suggestive”, but the proposed RfDs are considered protective against the tumour types seen in laboratory animal studies.

US Environmental Protection Agency.

Health effects document for perfluorooctanoic acid (PFOA). Peer review draft. February 2014. http://peerreview.versar.com/epa/pfoa/pdf/Health-Effects-Document-for-Perfluorooctanoic-Acid-(PFOA).pdf

Health effects document for perfluorooctane sulfonate (PFOS). Peer review draft. February 2014. http://peerreview.versar.com/epa/pfoa/pdf/Health-Effects-Document-for-Perfluorooctane-Sulfonate-(PFOS).pdf

 

The above items were taken from the June 2014 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here)