The UK Drinking Water Inspectorate has funded a project investigating the occurrence of veterinary medicines in ground and treated water in England and Wales. Using predictive models to estimate levels of the substances in ground water; their removal by different drinking water treatment processes; and potential human exposure for various population groups, 26 veterinary medicines of “potential concern” were initially identified. After these were subjected to more complex modelling, the estimated intake for the human population (from conventionally or advanced treated drinking water) was very close to or exceeded the Acceptable Daily Intake (ADI), prompting a call for further work to establish the potential risks, for 10 substances:

  • acetyl salicylic acid
  • altrenogest
  • apramycin
  • cefapirin
  • dicyclanil
  • florfenicol
  • lincomycin
  • luprostiol
  • monensin
  • sulfadiazine

For the remaining 16 veterinary medicines, estimated intake levels were around 10% of the ADI and, as such, are considered not to be a potential risk to consumer health. The substances are:

  • albendazole
  • amoxicillin
  • chlortetracycline
  • chlorsulon
  • cypermethrin
  • cyromazine
  • diazinon
  • enrofloxacin
  • eprinomectin
  • halofuginone
  • lasalocid
  • salinomycin
  • tiamulin
  • tilmicosin
  • trimethoprim
  • tylosin

Appendix 3 of the report contains reviews of available toxicity data on these 26 substances.

UK Drinking Water Inspectorate
Desk-based study of current knowledge on veterinary medicines in drinking water and estimation of potential levels. Report ref: DWI 70/2/235, December 2011. Prepared by The Food and Environment Research Agency.

The above item was taken from the May 2012 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).

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