In 2015 ECETOC concluded that, while the evidence supports respiratory sensitisation being a thresholded and dose-responsive phenomenon, the mechanisms involved in the process are unclear and there is uncertainty regarding the relevant routes of exposure. There is also currently no validated model for the identification of respiratory sensitisers. Therefore, ECETOC recently held a workshop to identify areas to drive improvement in the identification, classification and risk characterisation of respiratory sensitisers. Recognised problems included a failure to distinguish between sensitisation and irritation of the respiratory tract for the purposes of classification and labelling, and a lack of clarity with regards to minimum reporting requirements for clinicians.

European Centre for Ecotoxicology and Toxicology of Chemicals (2017). Chemical respiratory allergy: Clinical information and how to use it and improve it. Madrid, 27-28th October 2016. Workshop Report No. 33.


The above items were taken from the May 2017 issue of Toxicology and Regulatory News which is sent automatically to members of bibra.

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