According to the widely-accepted WHO/IPCS definition, an endocrine disruptor is “an exogenous substance or mixture that alters function(s) of the endocrine system and consequently causes adverse health effects in an intact organism, or its progeny, or (sub)populations”. Whether an adverse health effect can be plausibly linked to an endocrine mechanism can be determined through the use of adverse outcome pathways (AOPs). New guidance from ECETOC describes how to (i) identify the basic requirements of a defined AOP relevant to the endocrine system, and (ii) establish minimum scientific standards that allow for the use of AOPs in hazard and risk assessment, and in read-across.

European Centre for Ecotoxicology and Toxicology of Chemicals (2016). Guidance on assessment and application of adverse outcome pathways (AOPs) relevant to the endocrine system. Technical Report No. 128. http://www.ecetoc.org/wp-content/uploads/2016/12/ECETOC-TR-128-Assessment-and-application-of-AOPs-relevant-to-the-Endocrine-System.pdf

 

The above items were taken from the March 2017 issue of Toxicology and Regulatory News which is sent automatically to members of bibra.

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