ECHA has recently published a report discussing the current regulatory applicability of non-animal approaches to testing under the REACH, CLP and Biocidal Products regulations. Development of concepts such as the Integrated Approach to Testing and Assessment (IATA) and Adverse Outcome Pathways (AOPs) in recent years have facilitated a more widespread use of non-animal approaches to testing with regard to chemical safety assessment. This is particularly evident for “lower-tier” properties of substances (e.g. skin/eye irritation). A full replacement of animal testing is not yet foreseeable, notably due to the complexity of certain endpoints such as repeated dose toxicity.

European Chemicals Agency (2017). Non-animal approaches. Current status of regulatory applicability under the REACH, CLP and Biocidal Products regulations. November 2017. https://echa.europa.eu/documents/10162/22931011/non_animal_approcches_en.pdf/87ebb68f-2038-f597-fc33-f4003e9e7d7d

 

The above items were taken from the January-February 2018 issue of Toxicology and Regulatory News which is sent automatically to members of bibra.

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