EFSA has finalised its updated guidance on the use of the BMD approach in risk assessment, taking into account the experience gained over the last 7 years. EFSA confirms that the BMD approach (specifically, model averaging) is its preferred method for deriving points of departure (PoDs), e.g. for risk assessment or for calculating health criteria values (HCVs). The method is scientifically more advanced than traditionally-used no- and lowest-observed-adverse-effect levels (NOAELs and LOAELs) as it makes extended use of dose-response data, and provides a quantification of uncertainties in the dose-response data. EFSA notes that, on average, NOAEL/LOAEL and BMD approaches will result in comparable reference points, but that in some cases they may differ substantially (e.g. by an order of magnitude).

European Food Safety Authority (2017). Update: use of the benchmark dose approach in risk assessment. http://onlinelibrary.wiley.com/doi/10.2903/j.efsa.2017.4658/full

 

The above items were taken from the March 2017 issue of Toxicology and Regulatory News which is sent automatically to members of bibra.

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