In EFSA’s 4th revision of flavouring group evaluation 74 (on 19 aliphatic sulphides and thiols), a new 90-day oral rat study on methyl propyl trisulphide, the candidate substance for a subgroup of eight tri- and polysulphides, has been considered. The Panel decided that the results of this study would only be applicable for safety assessment if the test material (70% pure) can be clearly demonstrated to be representative of the commercial material (a mixture of 45% purity), and that potential reaction products of the other commercial components (mono-, di- and tri-sulphides) are not of safety concern. In line with previous EFSA evaluations, additional toxicity data are also required for the assessment of 2-methyl-4-oxopentane-2-thiol and 2-mercapto-2-methylpentan-1-ol. The remaining nine substances assessed are considered not to present a safety concern under existing uses and use levels.

European Food Safety Authority (2018). Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF). Scientific opinion on flavouring group evaluation 74, revision 4 (FGE.74Rev4): Consideration of aliphatic sulphides and thiols evaluated by JECFA (53rd and 61st meeting) structurally related to aliphatic and alicyclic mono-, di-, tri- and polysulphides with or without additional oxygenated functional groups from chemical group 20 evaluated by EFSA in FGE.08Rev5. https://efsa.onlinelibrary.wiley.com/doi/pdf/10.2903/j.efsa.2018.5167

 

The above items were taken from the May 2018 issue of Toxicology and Regulatory News which is sent automatically to members of bibra.

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