Phosphate and polyphosphate food additives have been evaluated numerous times by various Expert Groups. In this new evaluation, the EFSA Panel on Food Additives and Flavourings has derived a group acceptable daily intake (ADI) of 40 mg/kg bw (as phosphorus). The critical effect observed in a chronic rat study with sodium triphosphate was calcification of the kidney and tubular nephropathy, where the no-observed-adverse-effect level (NOAEL) was 76 mg phosphorus/kg bw/day. Adjusting for phosphorus in the rat diet, an intake of 167 mg phosphorus/kg bw/day was used as the point of departure. EFSA concluded that the group ADI is sufficiently protective for healthy adults, but not for individuals with impaired renal function. The Panel noted that exposure estimates exceeded the ADI for infants (over 16 weeks of age), toddlers and other children, and for high-consuming adolescents. Consumption of food supplements was also likely to result in the ADI being exceeded.

European Food Safety Authority (2019). Panel on Food Additives and Flavourings (FAF). Re-evaluation of phosphoric acid–phosphates – di-, tri- and polyphosphates (E 338-341, E 343, E 450-452) as food additives and the safety of proposed extension of use.


The above items were taken from the July 2019 issue of Toxicology and Regulatory News which is sent automatically to members of bibra.

News Home Guest Write For Us? Contact Us