EFSA has evaluated the safety of DEHCH when used as a plasticiser in PVC films for food-contact uses. DEHCH was not genotoxic in vitro or in vivo, and had no adverse effects at oral doses of up to 1000 mg/kg bw/day in repeated-dose toxicity tests (which included 90-day, prenatal, and two-generation studies) in unspecified species. However, a toxicokinetic study in rats raised the concern that DEHCH might accumulate in humans. Nevertheless, EFSA concluded that DEHCH in PVC films does not raise a safety concern under specified use conditions, so long as the migration limit of 0.05 mg/kg food is not exceeded.

European Food Safety Authority (2020). Panel on Food Contact Materials, Enzymes and Processing Aids (CEP). Safety assessment of the substance bis(2-ethylhexyl) cyclohexane-1,4-dicarboxylate, for use in food contact materials. https://efsa.onlinelibrary.wiley.com/doi/epdf/10.2903/j.efsa.2020.5973


The above items were taken from the March 2020 issue of Toxicology and Regulatory News which is sent automatically to members of bibra.

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