EFSA has recently issued a scientific opinion on carvone, which occurs naturally as both D- and L- isomers in food and is also used in food additives, pesticides, consumer products and medicines. The EFSA scientific committee could not establish an acceptable daily intake (ADI) for L-carvone due to a lack of toxicological data. For D-carvone, the benchmark dose level for a 10% increase in relative rat liver weight (BMDL10) seen in a 90-day oral study was used to establish an ADI of 0.6 mg/kg bw.

European Food Safety Authority. Scientific opinion on the safety assessment of carvone, considering all sources of exposure. EFSA Journal 2014, 12(7), 3806.http://www.efsa.europa.eu/en/efsajournal/doc/3806.pdf

The above items were taken from the September 2014 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here)

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