EFSA’s finalised scientific opinion on the human health effects of caffeine also considers its possible interactions with other components of energy drinks (taurine and D-glucurono-γ-lactone), alcohol and synephrine (which is present in combination with caffeine in some food supplements). In adults, single caffeine exposures (which may occur more than once a day) of up to 3 mg/kg bw are considered unlikely to induce clinically-relevant changes in blood pressure, myocardial blood flow, hydration status or body temperature. Habitual intakes of up to 6 mg/kg bw/day also do not raise safety concerns for non-pregnant adults in the general population. For pregnant women, 3 mg/kg bw/day is considered safe. The available information was insufficient to derive guidance values for children or adolescents, although the adult intake “may serve as a basis to derive single doses of caffeine and daily caffeine intakes of no concern for these population subgroups”.

European Food Safety Authority (2015). Panel on Dietetic Products, Nutrition and Allergies (NDA). Scientific opinion on the safety of caffeine. EFSA Journal 2015, 13(5), 4102. http://www.efsa.europa.eu/en/efsajournal/doc/4102.pdf



The above items were taken from the July 2015 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here)

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