Back in 2003, EFSA’s predecessor, the Scientific Committee on Food (SCF), established a tolerable upper intake level (UL) of 25 µg vitamin D/day for infants aged 0 to 24 months. The value was based on the absence of hypercalcaemia in two intervention studies on infants, and a lack of data meant that it could not be refined by EFSA in 2012. In the current (2018) draft update, the available data on daily vitamin D intake and potential adverse health outcomes are still not considered to be a sufficient basis for a UL on their own. However, a dose-response relationship between daily supplemental intake of vitamin D and mean achieved serum 25-hydroxy-vitamin D [25(OH)D] concentrations was established. A serum concentration of 200 nmol 25(OH)D/L or less is considered unlikely to pose a risk of adverse health outcomes in infants, so EFSA estimated the percentage of infants likely to exceed this value, given their vitamin D intakes. Based on these findings, EFSA retained the UL of 25 µg/day for infants aged up to 6 months, and set a new UL of 35 µg/day for those aged between 6 and 12 months. The safety of infant formulae containing vitamin D at a maximum content of 3 μg/100 kcal was also evaluated.

European Food Safety Authority (2018). Panel on Dietetic Products, Nutrition and Allergies (NDA). Update of the tolerable upper intake level for vitamin D for infants. Draft. http://www.efsa.europa.eu/sites/default/files/engage/180418.pdf

Supporting documents are available at http://www.efsa.europa.eu/en/consultations/call/180418

 

The above items were taken from the July 2018 issue of Toxicology and Regulatory News which is sent automatically to members of bibra.

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