Titanium dioxide (E 171, with <3.2% nanosized particles) is an authorised food colouring in the EU. There is evidence that titanium dioxide is potentially carcinogenic when inhaled, but it is not considered carcinogenic by the oral or dermal routes. Adverse effects in the reproductive systems of exposed rodents were identified in some studies using either non-food-grade titanium dioxide, or inadequately characterised nanomaterial (i.e. not E 171). In order to address this uncertainty to allow for an acceptable daily intake (ADI) to be established, EFSA recommended that an extended 90-day study, or a multi-generation or extended one-generation reproduction toxicity study, be carried out.

European Food Safety Authority (2016). Re-evaluation of titanium dioxide (E 171) as a food additive. EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS). http://onlinelibrary.wiley.com/doi/10.2903/j.efsa.2016.4545/full

 

The above items were taken from the November 2016 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here)

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