Benchmark Dose (BMD) methods are used by the EPA to estimate reference doses (RfDs) and concentrations (RfCs) to set standards for non-cancer human health effects. The BMD approach defines a point of departure for the calculation of such a reference value that is more independent of study design than no-observed-adverse-effect levels (NOAELs) and concentrations (NOAECs). The EPA has now finalised its Benchmark Dose Technical Guidance document on the application of the BMD approach, illustrated with examples using the agency’s software (BMDS).

US Environmental Protection Agency, Risk Assessment Forum. Benchmark Dose Technical Guidance, EPA/100/R-12/001. June 2012.

http://www.epa.gov/raf/publications/pdfs/benchmark_dose_guidance.pdf

The above item was taken from the July 2012 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).

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