The Agency has concluded that NMDRs do occur, however, they are not commonly identified in vivo, and are rarely seen in whole-organism studies after low-dose or long-term exposure. Significantly, the Agency considers that there is no reproducible evidence that the low-dose key biological events involved in NMDR expression are predictive of adverse outcomes in humans and, as such, the current testing strategies are “highly unlikely to mischaracterize” a chemical that has the potential for endocrine disruption.
US Environmental Protection Agency (EPA). State of the science evaluation: nonmonotonic dose responses as they apply to estrogen, androgen, and thyroid pathways and EPA testing and assessment procedures. Draft. June 2013.
The above item was taken from the August 2013 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).News Home Guest Write For Us? Contact Us