Under REACH, non-animal test methods are now the default recommended laboratory method to fill data gaps on skin sensitisation. In response to this, EURL ECVAM has published its views on their use. Key recommendations include the use of combinations of in vitro and in chemico methods approved by the Organisation for Economic Co-operation and Development (OECD), covering different key events within the defined adverse outcome pathway (AOP) for skin sensitisation. Where possible, such methods should be used instead of tests on laboratory animals (such as the mouse local lymph node assay, LLNA), as part of defined approaches (DAs), or integrated approaches to testing and assessment (IATAs).

European Union Reference Laboratory for Alternatives to Animal Testing (2017). EURL ECVAM recommendation on the use of non-animal approaches for skin sensitisation testing. http://publications.jrc.ec.europa.eu/repository/bitstream/JRC106410/eurl_ecvam_recommendation_on_non-animal_approaches_final.pdf

 

The above items were taken from the June 2017 issue of Toxicology and Regulatory News which is sent automatically to members of bibra.

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