The traditional monotonic dose-response curve (where toxicity increases with dose) may not necessarily apply to all chemicals. In a report drafted for EFSA by national authority experts from Austria (AGES), France (ANSES), Sweden (IMM) and the Netherlands (RIVM), evidence relevant to NMDRs (where toxicity decreases with increasing dose at some point in the dose-response spectrum, e.g. ‘low-dose’ effects, or when toxicity is maximal at intermediate doses) has been compiled for further evaluation. The most useful datasets were considered to be those covering quercetin, resveratrol, α-benzene hexachloride and methylmercury.

Beausoleil C et al. (2016). Review of non-monotonic dose-responses of substances for human risk assessment. EFSA Supporting Publication 2016:EN-1027. Austrian Agency for Health and Food Safety GmhH. French Agency for Food, Environment and Occupational Health and Safety. Swedish Institute of Environmental Medicine, Karolinska Institutet. Dutch National Institute for Public Health and the Environment. http://www.efsa.europa.eu/sites/default/files/scientific_output/files/main_documents/1027e.pdf
 

The above items were taken from the June 2016 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here)

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