The US FDA has requested public comment on its proposal to add 19 constituents or chemicals of concern to the Harmful and Potentially Harmful Constituent (HPHC) list for tobacco products, including electronic nicotine delivery systems (ENDS). Glycidol, ethylene glycol and diethylene glycol have been put forward as they meet the criteria for, respectively, carcinogenic potential, reproductive toxicity, and causing serious or irreversible acute health consequences. Ethylene glycol and all other suggested constituents (including propylene glycol) have been identified by NIOSH (the National Institute for Occupational Safety and Health) as being able to cause adverse respiratory effects, an additional qualifying criterion being considered by the US FDA.

US Food and Drug Administration (2019). Harmful and Potentially Harmful Constituents in Tobacco Products; Established List; Proposed Additions; Request for Comments. Federal Register. Vol. 84, No. 150. 38032-38035. Monday. August 5, 2019. Notices.


The above items were taken from the September 2019 issue of Toxicology and Regulatory News which is sent automatically to members of bibra.

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