The OECD extended one generation reproduction toxicity study (EOGRTS) was adopted by the OECD in July 2011 (OECD 443). A recent research paper reports on feasibility studies conducted on four chemicals tested when the guideline was still in draft form, and concludes that the results “illustrate the variety of reproductive and developmental endpoints which can be captured in this complex but manageable study design.” Although the test presents logistical challenges, its advantages over the two-generation study (OECD 416) include a higher standard of data generated and a substantial reduction in the numbers of animals used.

Fegert I et al. Reproductive Toxicology 2012, 34, 331.

http://dx.doi.org/10.1016/j.reprotox.2012.05.096

At a recent symposium, the importance of juvenile toxicity testing was emphasised, as the developing immune and nervous systems show a high sensitivity to chemical exposure. One possible suggestion was that the “already logistically demanding” EOGRTS be extended to include administering the test substance by gavage to pre-weaning pups (“to provide direct exposure in this critical developmental window”).

Piersma AH et al. Reproductive Toxicology 2012, 34, 482.

http://dx.doi.org/10.1016/j.reprotox.2012.04.010

 

The above item was taken from the October 2012 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).