The final version of the toxicological profile for acrylamide has been made available online by the US Agency for Toxic Substances and Disease Registry. The profile provides a thorough review of the toxicological and epidemiological data available for acrylamide and an evaluation of the risk it might pose to human health. The Agency has derived a minimal risk level (MRL) (an estimate of daily human exposure likely to be without appreciable risk of non-carcinogenic adverse effects over a specified exposure duration) of 0.01 mg/kg bw/day for acute (up to 14 days) oral exposure and an MRL of 0.001 mg/kg bw/day for any oral exposure of 15 days or greater.

The ATSDR has also announced that it has begun the development of the ‘Set 26’ toxicological profiles for:

  • trichloroethylene
  • tetrachloroethylene
  • hydrogen sulfide/carbonyl sulphide
  • glutaraldehyde
  • parathion

The Agency anticipates drafts of these reports to be made available for public comment in mid-October 2013.

US Agency for Toxic Substances and Disease Registry. Toxicological Profile for Acrylamide. December 2012. 

http://www.atsdr.cdc.gov/ToxProfiles/tp203.pdf

The above item was taken from the March 2013 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).

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