The final version of the toxicological profile for acrylamide has been made available online by the US Agency for Toxic Substances and Disease Registry. The profile provides a thorough review of the toxicological and epidemiological data available for acrylamide and an evaluation of the risk it might pose to human health. The Agency has derived a minimal risk level (MRL) (an estimate of daily human exposure likely to be without appreciable risk of non-carcinogenic adverse effects over a specified exposure duration) of 0.01 mg/kg bw/day for acute (up to 14 days) oral exposure and an MRL of 0.001 mg/kg bw/day for any oral exposure of 15 days or greater.

The ATSDR has also announced that it has begun the development of the ‘Set 26’ toxicological profiles for:

  • trichloroethylene
  • tetrachloroethylene
  • hydrogen sulfide/carbonyl sulphide
  • glutaraldehyde
  • parathion

The Agency anticipates drafts of these reports to be made available for public comment in mid-October 2013.

US Agency for Toxic Substances and Disease Registry. Toxicological Profile for Acrylamide. December 2012.

The above item was taken from the March 2013 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).

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