The US Agency for Toxic Substances and Disease Registry has made available online nine final toxicological profiles. These profiles provide a thorough review of the toxicological and epidemiological data for each substance, and an evaluation of the risk to human health from a number of different routes of exposure. Also developed in this process are Minimal Risk Levels (MRLs), defined as an estimate of daily human exposure to a substance that is likely to be without an appreciable risk of adverse non-cancer health effects over a specified duration of exposure.

  • 1,3-butadiene
  • cadmium
  • carbon monoxide
  • chromium
  • 1,4-dioxane
  • manganese
  • phosphate ester
  • flame retardants
  • radon
  • vanadium

In addition, the ATSDR website has been updated with several addenda to existing toxicological profiles. These are not peer-reviewed – unlike the main profiles – but provide information from the scientific literature which is intended to be read in conjunction with the full profile. Recent addenda have been published for:

  • 2,3-benzofuran
  • carbon disulfide
  • chlorinated dibenzo-para-dioxins
  • hydrogen sulfide
  • pentachlorophenol

US Agency for Toxic Substances and Disease Registry Toxicological Profiles.

All profiles and addenda are accessible through the alphabetical list.

The above item was taken from the January–February 2013 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).

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